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Smoking during pregnancy is associated with numerous fetal and developmental complications and reproductive dysfunctions in the offspring. Nicotine is one of the key chemicals of tobacco responsible for addiction. The present study was aimed to investigate the protective role of α-lipoic acid (ALA) during the transplacental nicotine-induced germ cell and DNA damage in the offspring of Swiss mice.

journal of basic and clinical physiology and pharmacology

α-Lipoic acid attenuates transplacental nicotine-induced germ cell and oxidative DNA damage in adult mice: ALA attenuates nicotine-induced transplacental toxicity