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Background:  Hattaraki pallye or prickly lettuce ( Lactuca scariola  Linn.) is one among several green leafy plants that grow in north Karnataka; it is usually consumed by the people of this region and is found to be antidiabetic in nature. The objective of this study is to evaluate hypoglycemic activities of supplementation with aqueous extract of prickly lettuce ( L. scariola ) leaves in vivo in acute and subchronic exposure with or without nickel (II) along with its glucose reduction capabilities with or without nickel (II) at pH 7.0 and 9.0 in vitro.

journal of basic and clinical physiology and pharmacology

Anti-diabetic effects of aqueous prickly lettuce ( Lactuca scariola  Linn.) leaves extract in alloxan-induced male diabetic rats treated with nickel (II)