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Background:  The preclinical incision pain models and clinical studies in healthy volunteers have demonstrated the central serotonergic analgesic mechanism, paracetamol analgesia. This has been evidenced by raised serotonin concentrations in the brain following paracetamol administration in a few studies. The inhibition of paracetamol analgesia by 5-HT 3  antagonists suggests that this analgesia is 5-HT 3  mediated. However, in a few studies, 5-HT 3  antagonists themselves exhibited an analgesic action. Various studies in this context stated intricate results. The present study was intended to understand the pharmacodynamic interaction between paracetamol and ondansetron in postoperative patients.

journal of basic and clinical physiology and pharmacology

Randomized, double-blind, placebo-controlled study to investigate the pharmacodynamic interaction of 5-HT 3  antagonist ondansetron and paracetamol in postoperative patients operated  in an ENT department under local anesthesia