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Background  Radiofrequency ablation (RFA) represents a treatment option for non-resectable liver malignancies. Larger ablations can be achieved with a temporary hepatic inflow occlusion (Pringle maneuver – PM). However, a PM can induce dehydration and carbonization of the target tissue. The objective of this study was to evaluate the impact of an intermittent PM on the ablation size.    Methods  Twenty-five multipolar RFAs were performed in porcine livers  ex vivo . A perfused glass tube was used to simulate a natural vessel. The following five test series (each n=5) were conducted: (1) continuous PM, (2–4) intermittent PM, and (5) no PM. Ablations were cut into half. Ablation area, minimal radius, and maximal radius were compared.    Results  No change in complete ablation size could be measured between the test series (p&gt;0.05). A small rim of native liver tissue was observed around the glass tube in the test series without PM. A significant increase of ablation area could be measured on the margin of the ablations with an intermittent PM, starting without hepatic inflow occlusion (p&lt;0.05).    Conclusion  An intermittent PM did not lead to smaller ablations compared to a continuous or no PM  ex vivo . Furthermore, an intermittent PM can increase the ablation area when initial hepatic inflow is succeeded by a PM.

Intermittent Pringle maneuver may be beneficial for radiofrequency ablations in situations with tumor-vessel proximity