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Syndromes of delusional misidentification and delusional reduplication are among the many neuropsychiatric conditions that affect both brain and behavior and pose challenges to mental health professionals. Fregoli syndrome is the delusional belief that one or more familiar persons, usually persecutors following the patient, repeatedly transform their appearance. There is a growing body of evidence that delusional misidentification syndromes (DMS), including Fregoli syndrome, have identifiable brain lesions largely related to the right hemisphere. In this article we describe a case report of Fregoli syndrome and discuss the relevant literature. Clinicians encountering DMS can frequently find mismatch with the current Diagnostic and Statistical Manual of Mental Disorders-4th edition-text revision (DSM-IV-TR) categories. It is not clear whether or not these syndromes should be regarded as separate disorders.

A patient with the Fregoli syndrome: a case report and discussion of the relevant literature