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As a kind of fast and efficient mixing equipment, micromixer has been applied to chemical reaction detection. Its application can not only save experimental samples but also reduce the experimental time. In micromixers, Tesla structure is widely used due to its simple structure and special flow mechanism. In this paper, CFD and response surface method are used to analyze and verify the flow field of the configuration of adding diamond obstacles in the Tesla mixer. The results show that the order of layout parameter weight from large to small is obstacle size &gt; vertical offset &gt; horizontal offset. And the Desirability was 0.806, the optimal diamond obstacle size is 46.35 μm and the optimal lateral offset is 18.78 μm. In addition, a constant value OF 20 μm is predicted as the optimal vertical offset of the micromixer. Compared with the Tesla-type micromixer without obstacles, the diamond-shaped barrier Tesla-type micromixer designed in this paper has higher mixing rate and lower pressure drop under the same conditions, which can be applied to chemical reactors, and can also help to improve the accuracy of chemical reaction. It can be demonstrated that the presented optimal design method of obstacles layout in Tesla mixer is a simple and effective technology to improve the liquid mixing in microfluidic devices, and it has a broad application prospect in chemical engineering.

CFD analysis and RSM optimization of obstacle layout in Tesla micromixer