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Background:  Some studies showed associations of the minor T allele of the C1858T single nucleotide polymorphism (SNP) corresponding to the R620W amino acid substitution of protein tyrosine phosphatase ( PTPN22 ) with multiple autoimmune diseases, including systemic lupus erythematosus (SLE).

international journal of adolescent medicine and health

R620W polymorphism of protein tyrosine phosphatase PTPN22 in Egyptian children and adolescents with systemic lupus erythematosus: relation to thyroid autoimmunity