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With the help of a four-point-bend of fatigue rig, high-cycle fatigue tests were carried out on an Ti–6.5Al–2Zr-1Mo-1V titanium alloy at room temperature, 20 Hz and  R  = 0.1 in ambient air. The test results indicated that the fatigue strength of base metal, 888 MPa, is about 120% of yield strength. The fatigue strength of joints is 814 MPa. It is about 110% of yield strength of base metal. When the loading stress is higher, the fatigue failure region is located in middle weld zone of weld face, which the cracks are propagated along coarse  β  phase’s grain boundary. When the loading stress is lower, the fatigue failure region is located between the incomplete recrystallization zone and base metal. The crack nucleation resistance gradually increases from the WN to HAZ with the variable of loading stress and  β  phase (little  α′  phases)→  α  +  β  phase→  α  phase.

Microstructural Properties and Four-Point Bend Fatigue Behavior of Ti-6.5Al-2Zr-1Mo-1V Welded Joints by Electron Beam Welding