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Background : After cessation of estrogen secretion by the ovaries at menopause, all estrogens and almost all androgens acting in the skin of postmenopausal women are synthesized locally from dehydroepiandrosterone (DHEA), a prohormone of adrenal origin that progressively declines with age.

hormone molecular biology and clinical investigation

Effect of long-term topical application of dehydroepiandrosterone (DHEA) and oral estrogens on morphology, cell proliferation, procollagen A1 and androgen receptor levels in rat skin