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Background : The human breast contains all the enzymes responsible for local bioformation of estradiol (E 2 ). Two principal pathways are implicated in the last steps of E 2  formation: the ‘aromatase’ which transforms androgens into estrogens, and the ‘sulfatase’ which converts estrogen sulfates into active unconjugated estrogens; activities found in both normal and cancerous breast. Aromatase inhibition by anti-aromatase agents is largely used with very positive results in the treatment of breast cancer patients. In this study, the effects of the natural androgens androstenedione and testosterone were explored on aromatase activity in a stable aromatase-expressing estrogen receptor-positive human breast cancer cell line MCF-7aro.

Inhibition of aromatase activity in MCF-7aro human breast cancer cells by the natural androgens testosterone and androstenedione