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1,4-Bis(6-aryl-1,2,4-triazolo[3,4- b ]-[1,3,4]thiadiazol-3-yl)­benzenes ( 3 ) were synthesized in high yields by reaction of bis(4-amino-5-mercapto-1,2,4-triazol-3-yl)benzene ( 1 ) with carboxylic acids  2  in the presence of POCl 3  and tetrabutylammonium iodide as catalyst. The MTT assay indicated that compounds  3a–i  possess inhibitory activity against the proliferation of HepG-2 (liver cancer), A549-1 (lung cancer) and 231-2 (breast cancer).

Synthesis and anticancer activities of 1,4-bis(6-aryl-1,2,4-triazolo[3,4- b ]-[1,3,4]thiadiazole-3-yl)benzene derivatives