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Eight 6-aryl-2,3,4,5-tetrahydro-7,8,9,10-tetrahydro-l lH-pyrazolo [3,4-a] thiazolo [2,3-b] quinazolines were prepared 5a-h from the respective 5H-5-aryl-6,7,8,9-tetrahydro thiazolo[2,3b]quinazolin-3(2H)-ones by a cycloaddition reaction of hydrazine / Phenylhydrazine. The thiazoloquinazolinones, on the other hand were obtained from a fusion reaction of 4-aryl-3,4,5,6,7,8hexahydroquinazonin-2-thiones with chloroacetic acid. The final compounds were purified and characterized by their analytical and spectral (IR & HMR) data. Their pharmacological studies are in progress.

heterocyclic communications

DEVELOPMENT OF NEW MOLECULAR ENTITIES AS POTENT NON-STEROIDAL NON-ACIDIC ANTI-INFLAMMATORY AGENTS - PART-I: SYNTHESIS OF SOME SUBSTITUTED PYRAZOLO-[3, 4-a] THIOZOLO [2', 3'-b] QUINAZOLINES