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A lot of diazepine derivatives are known to have diverse and remarkable pharmacological activities. The most investigated group of diazepines is 1,4-diazepine derivatives well-known tranquillizers and anticonvulsants (1,2). In contrast to 1,4-diazepines, data on pharmacological activity of 1,2-diazepines are very poor. There is a structure related to the title compounds described: pyrrolo[3,4-d][1,2]diazepines (3), however there are no pharmacological data on these compounds. Our report includes data about synthesis of benzo[f][1,2]diazepino[5,4,3-c,d]indoles 4, their effect on CNS functioning and its comparison with those of related six-membered analogue pyrroloacridine 3.

OCTAHYDRO DERIVATIVES OF A NOVEL HETEROCYCLIC SYSTEM BENZO[f][1,2]DIAZEPINO[5,4,3-c,d]INDOLES