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A series of novel imidazo[4,5- b ]pyridine derivatives were synthesized and their structures were characterized by NMR spectroscopy, mass spectrometry and elemental analysis. The results of bioassays showed that some compounds exhibit good fungicidal activity against  Puccinia polysora  In particular, compound  7b  showed an EC 50  value of 4.00 mg/L, which was comparable with that of tebuconazole. Besides, preliminary structure-activity relationship was discussed.

Synthesis and fungicidal activity of novel imidazo[4, 5- b ]pyridine derivatives