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Ten 5-bromoindole-2-carboxamides were synthesized, characterized and evaluated for antibacterial activity against pathogenic Gram-negative bacteria  Klebsiella pneumoniae ,  Escherichia coli ,  Pseudomonas aeruginosa  and  Salmonella  Typhi using gentamicin and ciprofloxacin as internal standards. Compounds  7a–c ,  7g  and  7h  exhibit high antibacterial activity with a minimum inhibitory concentration (MIC) of 0.35–1.25 μg/mL. Compounds  7a–c  exhibit antibacterial activities that are higher than those of the standards against  E. coli  and  P. aeruginosa .

5-Bromo-1-(4-chlorobenzyl)-1 H -indole-2-carboxamides as new potent antibacterial agents