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Syntheses of 3-(4-arylthieno[2,3- d ]pyrimidin-2-yl)-2 H -chromen-2-ones  5  by the reaction of 2-iminocoumarin-3-carboxamides  1  with (2-aminothiophen-3-yl)(aryl)methanones  2  and by the alternative Suzuki coupling of 4-chlorothieno[2,3- d ]pyrimidin-2-yl-2 H -chromen-2-one  7  with arylboronic acids were developed. Compound  5d  showed higher antimicrobial activity against  Staphylococcus aureus  than the reference drug streptomycin.

Synthesis and antimicrobial evaluation of 3-(4-arylthieno[2,3- d ]pyrimidin-2-yl)- 2 H -chromen-2-ones