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New 1-aryl-4-[(aziridine-1-yl)diarylmethyl]-5-methyl-1 H -1,2,3-triazole derivatives  7a–i  were synthesized by a one-pot reaction of diaryl-(1-aryl-5-methyl- 1H -1,2,3-triazol-4-yl)methanols  6a–i  derived from 1-aryl-5-methyl-1 H -1,2,3-triazole-4-carboxylic acids  4a–c . Structures of compounds  7a–i  were confirmed by analysis of proton nuclear magnetic resonance ( 1 H NMR) and carbon-13 nuclear magnetic resonance ( 13 C NMR), mass spectrometry (MS) and infrared (IR) data. The structure of compound  7f  was studied by X-ray diffraction analysis. The anticancer activities of compounds  7a–i  against human leukemia HL-60 cells and human hepatoma G2 cells were evaluated. Some of the compounds are highly active.

Design, synthesis and anticancer activity evaluation of aziridine-1,2,3-triazole hybrid derivatives