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Eight new sugar-substituted isoxazoles were synthesized by a 1,3-dipolar cycloaddition reaction of aromatic nitrile oxides with carbohydrate-substituted alkynes. Products were screened for antimycobacterial activity against the  Mycobacterium tuberculosis H37Rv  strain. Four compounds,  5e–h , significantly inhibit growth of the bacterial strain with a minimum inhibitory concentration (MIC) of 3.125 μg/mL.

Synthesis of carbohydrate-substituted isoxazoles and evaluation of their antitubercular activity