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Synthesis of new 1,2-dihydro-3 H -pyrazolo[3,4- d ] pyrimidin-3-ones  4–6  starting with ethyl 4-hydroxy-2-methylthio-pyrimidine-5-carboxylate ( 1 ) under classical heating and microwave-induced conditions is reported. The antibacterial activities of the synthesized compounds were evaluated using chloramphenicol and streptomycin as reference drugs.

Microwave-assisted synthesis and antibacterial evaluation of new derivatives of 1,2-dihydro-3 H -pyrazolo[3,4- d ]pyrimidin-3-one