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Synthesis, characterization, and investigation of antimicrobial activities of nine novel imidazolylthiazoles are presented. Their structures were determined using  1 H NMR,  13 C NMR, and elemental analysis. Compounds  3e  and  3i  show very strong or strong bacteriostatic or bactericidal activity [minimal bactericidal concentration/minimal inhibitory concentration (MIC)=2–64] against  Staphylococcus  spp. (MIC=7.81–15.62 μg/mL),  Micrococcus luteus  ATCC 10240 (MIC=1.95–3.91 μg/mL), and  Bacillus  spp. (MIC=3.91–15.62 μg/mL). Compounds  3e  and  3i  also show the highest fungicidal effect (minimal fungicidal concentration/MIC=2–4) against reference strains of fungi belonging to  Candida  spp. with MIC ranging from 3.91 to 31.25 μg/mL.

Synthesis and biological evaluation of novel 2-(1 H -imidazol-2-ylmethylidene)hydrazinyl- 1,3-thiazoles as potential antimicrobial agents