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A series of 38 new derivatives of cyclic imides containing silicon in the structure was synthesized and characterized by  1 H NMR, ESI-MS, and elemental analysis. Selected compounds ( 1l,m ,  1g ,  1o,p ,  2l,m , and  2o,p ) were tested for their cytotoxic properties in human chronic myelogenous leukemia (K562), human cervical cancer (HeLa), and normal endothelial cells (HUVEC). Seven compounds showed significant cytotoxicity. In addition, two compounds ( 1l  and  2l ) were tested toward affinity for 5-HT 1A , 5-HT 6 , and 5-HT 7  serotonin receptors, and all aryl/heteroarylopiperazino derivatives were tested for antimicrobial activity. The compounds tested toward affinity for selected serotonin receptors showed high and moderate affinity for 5-HT 1A  and 5-HT 7 , while the antimicrobial activity of tested compounds was not significant.

heterocyclic communications

Synthesis and preliminary studies of biological activity of amino derivatives of 4-azatricyclo- [5.2.1.0 2,6 ]dec-8-ene-3,5-dione with silicon in the structure