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A series of novel 3-substituted coumarinyl-triazine derivatives were designed and synthesized from 3-carboxycoumarins via consecutive Knoevenagel and Pinner reactions in water. All synthesized compounds were characterized by IR,  1 H NMR,  13 C NMR, MS, and elemental analysis. Further,  in vitro  screening was carried out against four bacterial strains ( Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and  Salmonella typhi ) and two fungal strains ( Aspergillus niger  and  Aspergillus clavatus ).

Design, synthesis, antibacterial, and antifungal studies of novel 3-substituted coumarinyl-triazine derivatives