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A new efficient method of synthesizing 3-cyano-pyridine-2(1 H )-ones containing variable substituents at position 4 and various aromatic substituents at position 1 of the pyridinone ring has been developed. The method is based on the reaction of ylidenecyanoacetic acid ethyl esters with dimethylformamide dimethyl acetal, the re-amination of obtained derivatives with several aromatic amines in glacial acetic acid and the final cyclization of the intermediate products to targeted N-aryl-3-cyano-pyridine-2(1 H )-ones. The condensation reactions of some of the synthesized compounds with several aldehydes have been investigated.

Convenient synthetic route to 3-cyanopyridine-2(1 H )-one derivatives with aromatic substituents