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Condensation of Gewald’s thiophenes substituted with a dimethylaminomethyleneamino group at position 2 with primary amines yields 5/6-aryl-thieno[2,3- d ]pyrimidin-4-ones with variable substituents at the N3 position.

Facile approach to the synthesis of substituted thieno[2,3- d ]pyrimidin-4-ones