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ASP  was used to synthesize FeNP A . They were characterized by UV-vis spectroscopy, FT-IR, TEM, SEM, XRD and ZP. The aim of this study was to evaluate in vitro cytotoxic activity and antioxidant acitivities of FeNP A  and  ASP . The antioxidant properties were evaluated using DPPH, ABTS +  and H 2 O 2  assays. FeNP A  had higher antioxidant activity comparing to  ASP  according to DPPH (IC 50 : 3.48 μg/mL) and ABTS +  (60.52%) assays. Anti-cancer activities of FeNP A  and  ASP  were investigated in breast cancer, melanoma and control cell lines. FeNP A  was more cytotoxic than  ASP  in MCF-7, MeWo, CHL-1, and HEL 299 cells. FeNP A  had shown that mitochondria induce apoptosis through stress in MDA-MB-231, and cells MeWo.  ASP  also induced apoptosis 2.23-fold in MCF-7 cells. Progesterone receptor gene expression showed a 10-fold increase in a hormone-dependent MCF-7 cell line in  ASP , and FeNP A  treatment. Expressions of BCL6, CXCL12, DNAJC15, RB1 and TPM1 in melanoma cancer cell lines were significantly increased in  ASP  and FeNP A  administration. It had been shown that FeNP A  regulates gene expressions that may be considered important in terms of prognosis in breast cancer and melanoma cell lines and it is suggested that gene expressions regulated by FeNP A  are also evaluated in animal models in vivo.

Structural characterization, antioxidant and cytotoxic effects of iron nanoparticles synthesized using Asphodelus aestivus Brot. aqueous extract