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In recent years, the proliferation of coronavirus disease has profoundly affected the world. The vitality of urban space is difficult to recover in the short term. Therefore, in the early stage of human-to-human transmission of the epidemic, we need to determine the potential urban agglomeration space as soon as possible, the timely find of hidden danger areas, and carry out spatial optimization to prevent the further spread of the epidemic. This becomes the urgent problem at the moment. Jinan is the capital city of Shandong Province, and the mega-city of China. The study is focused on the main urban area within the bypass. This study used spatial data methods such as spatial grammar and GIS technology. First, we analyzed the spatial topological properties of urban road network during the epidemic. Then, we carried out spatial autocorrelation analysis on the topological attributes to get the shape of urban spatial clustering layout during the epidemic. Finally, the thesis crawled through various types of infrastructure points-of-interest and conducted nuclear density analysis to get the dynamic trend of urban space in Jinan. The research results showed that there is significant space for agglomeration in the main urban area of Jinan. The areas with strong agglomeration are basically located in tourism areas, school areas, business areas, living circle areas of residential communities in Licheng and Lixia districts, transportation hub areas in Tianqiao District, and high-tech industrial areas in Lixia District. Topography, water body, greening, and parks could effectively reduce the concentration of human flow, and are important areas to relieve the potential abnormal epidemic. This study provided a new method for detecting epidemic prevention and control areas, optimizing urban space layout and formulating prevention and control strategies in the early stage of human-to-human epidemic transmission and lack of case surveillance data and control measures.

A new method to explore the abnormal space of urban hidden dangers under epidemic outbreak and its prevention and control: A case study of Jinan City