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A novel kind of thermo and pH-responsive hydrogels was prepared by reacting N,O-carboxymethyl chitosan (NOCC) with amino-telechelic poly(Nisopropylacrylamide) (PNIPAAm-NH 2 ) as a drug delivery carrier. The hydrogels were characterized by FT-IR and  1 H-NMR techniques. The phase transition behavior of the hydrogels was found to be dependent on the NOCC/PNIPAAm-NH 2  weight ratio and pH value of the medium. The hydrogels with a higher content of PNIPAAm showed a definite phase transition at 32 °C as it occurs in pure PNIPAAm. For the release study, NOCC-g-PNIPAAm beads were prepared using glutaraldehyde (GA) as a crosslinking agent. The swelling ratio of the beads was higher in pH 2.1 than pH 7.4. Moreover, the swelling ratio of the beads decreased with the increase in PNIPAAm content of the beads. The release profile of NOCCg- PNIPAAm beads showed a slower and controlled release of the entrapped ketoprofen, and found that the release behaviour was influenced by both the pH and temperature of the medium. It is expected that these smart hydrogels may be useful to develop drug delivery systems with improved drug loading capacity and controlled release behaviour.

A Novel pH and Thermo-sensitive N,O-Carboxymethyl Chitosan-graft-Poly(N-isopropylacrylamide) Hydrogel for Controlled Drug Delivery