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Paclitaxel is an antineoplastic agent derived from the bark of the Pacific Yew Tree ( Taxus brevifolia ). Oral administration of the pure drug is problematic as it has a poor absorption due to its poor solubility in aqueous media. A specific water-soluble prodrug - PP7 - has been introduced by coupling the drug with a water-soluble polymer. For any kind of medical application and administration, knowledge of the binary isobaric phase-diagram is important since it gives information about solubility, phase transitions and the corresponding compositions. The system PP7 + H 2 O was studied calorimetrically from -20°C and shows the typical behaviour of an eutectic system. The properties of the phase diagram are discussed in view of other solution properties of the system presented earlier.

Calorimetric investigation of the phase behaviour of the binary system 7-mPEG 5000-succinyloxymethyloxycarbonyl- Paclitaxel (PP7)/water