English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Surface modified self-nanoemulsifying formulations (SNEFs) loaded with gentamicin were formulated using suitable blends of soybean oil, a mixture of Kolliphor ®  P188 and Kolliphor ®  EL as surfactants, and Transcutol ®  HP as co-surfactant, and administered orally to white albino rats for evaluation of anti-pneumococcal activity against  Streptococcus pneumoniae . Droplet size and zeta potential measurements showed that SNEFs had mean droplet sizes in the range of 80.7±0.5–210.2±0.0, and were stable with mean zeta potential in the range of –25.2±3.0 to –42.5±1.3 mV. Preliminary screening against  S. pneumoniae  in vitro revealed that gentamicin-loaded SNEFs had better bacterial inhibition than the standard drug, and at a low minimum inhibitory concentration (MIC) of 2.5 mg/mL. Gentamicin delivered into cerebrospinal fluid of rats from orally administered SNEFs produced a prolonged and enhanced activity against  S. pneumoniae  at a dose of 7 mg/kg than the standard drug at the same dose. Hence, results from this study showed that the activity of gentamicin against  S. pneumoniae  was improved by formulation as surface modified SNEFs.

Formulation of gentamicin as surface modified self-nanoemulsifying formulations (SNEFs) improves its anti-pneumococcal activity