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In transplant patients receiving de novo anticalcineurin-free sirolimus (SRL)-based immunosuppression, we determined the influence of cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette, sub-family B (MDR/TAP), member (ABCB1) genotypes on SRL blood levels and medium-term relevant clinical outcomes, in order to improve effectiveness of immunosuppression strategies when anti-mammalian target of rapamycin (anti-mTOR) inhibitor is indicated for clinical reasons.

drug metabolism and personalized therapy

Influence of genetic polymorphisms of  CYP3A5  and  ABCB1  on sirolimus pharmacokinetics, patient and graft survival and other clinical outcomes in renal transplant