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This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.

A REVIEW ON THE RELATION BETWEEN THE BRAIN-SERUM CONCENTRATION RATIO OF DRUGS AND THE INFLUENCE OF P-GLYCOPROTEIN