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Background:  Mitragyna speciosa  leaves have been abused by drug addicts as some of the alkaloids (mainly mitragynine) from the plant possess opiate and cocaine-like effects. These bring to its prohibition in Malaysia in 2004 as consumption of  M. speciosa  leaves has been perceived to lead to the abuse of other drugs such as cannabis and heroin.

drug metabolism and drug interactions

Mitragyna speciosa  Korth leaves extracts induced the CYP450 catalyzed aminopyrine-N-demethylase (APND) and UDP-glucuronosyl transferase (UGT) activities in male Sprague-Dawley rat livers