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Background:  Cytochrome P450 2C19 is responsible for the metabolism of many drugs, including the activation of clopidogrel. The allele  CYP2C19*17  is associated with ultra-rapid metabolizer phenotypes by increasing gene transcription. This study tests to what extent  CYP2C19*17  enhances CYP2C19 expression in human liver and whether additional regulatory variants contribute to variation in CYP2C19 expression.

Regulatory polymorphisms in CYP2C19 affecting hepatic expression