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Background:  Statins are indicated for prevention of atherosclerotic cardiovascular disease. Metabolism of certain statins involves the cytochrome P450 3A (CYP3A) enzymes, and  CYP3A4*22  significantly influences the dose needed for achieving optimal lipid control for atorvastatin, simvastatin, and lovastatin.  CYP3A4/5  combined genotype approaches have proved useful in some studies involving CYP3A substrates. We intend to compare a combined genotype analysis to our previously reported single gene  CYP3A4  analysis.

CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control