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Among the different orientations in biosemiotics, those moved by Peircean ideas tend to agree that the organization of non-living parts into organisms cannot be made intelligible without supplementing the traditional resources of the physical sciences with novel kinds of causation. This is particularly true with regard to  semiosis  – the influence by which signs mediate the determination of interpretants by their objects.

Semiosis and Emergence: The place of biosemiotics in an evolutionary conception of nature