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Forward Osmosis (FO)-Nanofiltration (NF) integration as the final product polishing step enables high concentration of acetic acid output through continuous dehydration of fermentation derived product. A mathematical transport model has been developed based on external and internal concentration polarization modulus of FO and extended Nernst–Plank equation for NF to capture the flux and rejection trends from those membranes. The modular designed production scheme ensured high flux (45 Lm −2  h −1 ), concentration (962 g L −1 ) and purity (&gt;98 %) of acetic acid under non-neutralization condition. Excellent performance of the model is reflected in low relative error (&lt;0.05), high Willmott d-index (&gt;0.97) and high correlation coefficient (&gt;0.98).

Concentration Enrichment of Fermentation Derived Acetic Acid: Transport Modeling of Forward Osmosis-Nanofiltration Integrated System