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In this work, we consider ionic flow through ion channels for an ionic mixture of a cation species (positively charged ions) and an anion species (negatively charged ions), and examine effects of a positive permanent charge on fluxes of the cation species and the anion species. For an ion species, and for any given boundary conditions and channel geometry,we introduce a ratio _(Q) = J(Q)/J(0) between the flux J(Q) of the ion species associated with a permanent charge Q and the flux J(0) associated with zero permanent charge. The flux ratio _(Q) is a suitable quantity for measuring an effect of the permanent charge Q: if _(Q) &gt; 1, then the flux is enhanced by Q; if _ &lt; 1, then the flux is reduced by Q. Based on analysis of Poisson-Nernst-Planck models for ionic flows, a universal property of permanent charge effects is obtained: for a positive permanent charge Q, if _1(Q) is the flux ratio for the cation species and _2(Q) is the flux ratio for the anion species, then _1(Q) &lt; _2(Q), independent of boundary conditions and channel geometry. The statement is sharp in the sense that, at least for a given small positive Q, depending on boundary conditions and channel geometry, each of the followings indeed occurs: (i) _1(Q) &lt; 1 &lt; _2(Q); (ii) 1 &lt; _1(Q) &lt; _2(Q); (iii) _1(Q) &lt; _2(Q) &lt; 1. Analogous statements hold true for negative permanent charges with the inequalities reversed. It is also shown that the quantity _(Q) = |J(Q) − J(0)| may not be suitable for comparing the effects of permanent charges on cation flux and on anion flux. More precisely, for some positive permanent charge Q, if _1(Q) is associated with the cation species and _2(Q) is associated with the anion species, then, depending on boundary conditions and channel geometry, each of the followings is possible: (a) _1(Q) &gt; _2(Q); (b) _1(Q) &lt; _2(Q).

A Flux Ratio and a Universal Property of Permanent Charges Effects on Fluxes