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Cisplatin is an anticancer drug widely used in the treatment of a wide range of solid tumours (head and neck, lung, bladder etc.), testicular and ovarian cancers. Because of its severe toxicity profile and spontaneous development of drug resistance in tumours, a number of Pt(II) complexes have been synthesised and tested for anti-tumour activity. Some of the investigations have focused on using ligands bearing donor atoms other than N (e.g., S, P, O). Two new mixed Pt(II)complexes of the general formula  cis -[Pt(NH3)LCl2 ] where L is 3-thiolanespiro-5′ -hydantoin and 4-thio-1 H -tetrahydropyranspiro-5′-hydantoin were synthesised. The complexes were studied by elemental analysis, melting points, IR and  1 H NMR spectra. The hybrid DFT calculations were used for optimisation of the structure geometries of the ligands  III ,  IV  and their Pt(II) complexes  V  and  VI . The structural parameters so calculated, such as bond lengths and angles, are in good agreement with the experimental data for similar hydantoins and their platinum complexes. The results showed that the geometries of complexes  V  and  VI  are plane square and the bounding of ligands  III  and  IV  with platinum ions is effected by the sulphur atom from the cyclic ring. The complexes thus obtained were chemically examined in comparison with previously synthesised and published complexes of the general formula  cis -[PtL2 Cl2] ( VII  and  VIII  ) with the same ligands. The new compounds  V  and  VI , as well as the previously investigated complexes ( VII  and  VIII  ), were analysed for cytotoxicity in vitro on SKW-3 and HL-60 human tumour cell lines. The results showed that all the complexes exerted concentration-dependent anti-proliferative activity. Q c 2015 Institute of Chemistry, Slovak Academy of Sciences

chemical papers

Synthesis, DFT calculations and characterisation of new mixed Pt(II) complexes with 3-thiolanespiro-5′ 1-hydantoin and 4-thio-1 H -tetrahydropyranspiro-5′-hydantoin ‡