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Using microbial endophytes to produce bioactive compounds is a reliable scientific method. This investigation aimed to use the  Acacia  plant for isolating an endophytic fungal strain that has a bio-ability to produce a bio-crude extract. This study also encompassed the assessment of the extract’s biological efficacy as an antibacterial and anticancer agent. Samples of the  Acacia  plant were collected from “Shuaib Huraymila,” in Riyadh, Saudi Arabia. The isolation and identification of fungal endophytes was done, and then, the production of crude extract was performed using the isolated endophytes. The profile gas chromatography-mass spectroscopy of the extract was determined, followed by the assessment of its biological activity against drug-resistant infections and cancer cells through in vitro examination. The findings showed that the fungal endophyte was  Alternaria  ( Alternaria sorghi ), according to internal transcribed spacer sequencing and basic local alignment search tool analysis. The minimum inhibitory concentrations of the extract were 9.1 and 4.5 mg/mL for methicillin-resistant  Staphylococcus aureus  and drug-resistant  Candida auris , respectively, and the IC50% values were 46.6 and 23.7 mg/mL for MCF-7 and A549, respectively. The findings showed that this strain had no antagonistic action against  Culex pipiens . This study concluded that the fungal endophyte isolated from the  Acacia  plant has the bio-ability to produce antimicrobial and anticancer agents.

GC-MS profile of extracts of an endophytic fungus Alternaria and evaluation of its anticancer and antibacterial potentialities