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A green biosynthesis of silver nanoparticles (AgNPs) decorated  Mentha longifolia  root extract-functionalized graphene oxide (GO) nanohybrid material has been described. Initially, the  Mentha longifolia  root was coated on GO’s surface. The phytochemicals of the plant acted as reducing agent for reduction of silver ions and GO to form the rGO- Mentha /Ag nanocomposite. The nanocomposite was characterized using FE-SEM, EDX, FT-IR, TEM, elemental mapping, and XRD analysis. The cells treated with rGO- Mentha /Ag nanocomposite were assessed by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay for 48 h about the cytotoxicity and anti-human ovarian cancer properties on normal (HUVEC) and human ovarian cancer cell lines, i.e., SKOV3 and A2780. The IC 50  of rGO- Mentha /Ag nanocomposite were 181.2 and 196.4 µg/mL against SKOV3 and A2780cell lines, respectively. The viability of malignant human ovarian cell line reduced dose-dependently in the presence of rGO- Mentha /Ag nanocomposite. After clinical study, rGO- Mentha /Ag nanocomposite can be introduced as a novel composite in the treatment of human ovarian cancer.

Green supported silver nanoparticles over modified reduced graphene oxide: Investigation of its antioxidant and anti-ovarian cancer effects