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This article aimed at the synthesis and molecular docking assessment of new diimine Schiff base ligand, namely 2-(( E )-(2-(( Z )-2-(4-chlorophenyl)-2-hydroxyvinyl)hydrazono) methyl)-6-methoxyphenol (methoxy-diim), via the condensation of 1-(4-chloro-phenyl)-2-hydrazino-ethenol compound with 2-(( E )-(2-(( Z )-2-(4-chlorophenyl)-2-hydroxy vinyl) hydrazono)methyl)-6-methoxyphenol in acetic acid as well as the preparation of new binuclear complexes of Co( ii ), Ni( ii ), Cu( ii ), and Zn( ii ). The following synthesized complexes were prepared in a ratio of 2:1 (metal/ligand). The  1 H-NMR, UV-Vis, and FTIR spectroscopic data; molar conductivity measurements; and microanalytical, XRD, TGA/DTG, and biological studies were carried out to determine the molecular structure of these complexes. According to the spectroscopic analysis, the two central metal ions were coordinated with the diamine ligand via the nitrogen of the hydrazine and oxygen of the hydroxyl groups for the first metal ions and via the nitrogen of the hydrazine and oxygen of the phenol group for the second metal ions. Molecular docking for the free ligand was carried out against the breast cancer  3hb5 -oxidoreductase and the  4o1v -protein binding kidney cancer and COVID-19 protease, and good results were obtained.

open chemistry

Utilization and simulation of innovative new binuclear Co( ii ), Ni( ii ), Cu( ii ), and Zn( ii ) diimine Schiff base complexes in sterilization and coronavirus resistance (Covid-19)