English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The purpose of this work was to prepare Schiff base ligands containing quinoline moiety and using them for preparing Cu( ii ) and Zn( ii ) complexes. Four bidentate Schiff base ligands (SL 1 –SL 4 ) with quinoline hydrazine scaffold and a series of mononuclear Cu( ii ) and Zn( ii ) complexes were successfully prepared and characterized. The  in vitro  antibacterial and antifungal potential experimentation revealed that the ligands exhibited moderate antibacterial activity against the Gram-positive bacterial types and were inactive against the Gram-negative bacteria and the fungus strains. The metal complexes showed some enhancement in the activity against the Gram-positive bacterial strains and were inactive against the Gram-negative bacteria and the fungus strains similar to the parent ligands. The complex [Cu(SL 1 ) 2 ] was the most toxic compound against both Gram-positive  S. aureus  and  E. faecalis  bacteria. The  in silico  physicochemical investigation revealed that the ligand SL 4  showed highest  in silico  absorption (82.61%) and the two complexes [Cu(SL 4 ) 2 ] and [Zn(SL 4 ) 2 ] showed highest  in silico  absorption with 56.23% for both compounds. The  in silico  pharmacokinetics predictions showed that the ligands have high gastrointestinal (GI) absorption and the complexes showed low GI absorption. The ligands showed a good bioavailability score of 0.55 where the complexes showed moderate to poor bioavailability.

open chemistry

New Schiff bases of 2-(quinolin-8-yloxy)acetohydrazide and their Cu( ii ), and Zn( ii ) metal complexes: their  in vitro  antimicrobial potentials and  in silico  physicochemical and pharmacokinetics properties