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A series of new 2-phenyl-7-methyl-1,8-naphthyridine derivatives with variable substituents at C3 were synthesized for an  in vitro  evaluation of their anticancer activity against human breast cancer cell line (MCF7). On one hand, compounds  3f ,  6f ,  8c , and  10b  showed IC 50  values (6.53, 7.88, 7.89, 7.79 μM, respectively) compared to that of the mentioned drug staurosparine (IC 50  = 4.51 μM). On the other hand, derivatives  10c ,  8d ,  4d ,  10f  and  8b  displayed better activity than staurosporin with IC 50  values (1.47, 1.62, 1.68, 2.30, 3.19 μM, respectively).

Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line