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Background:  Asthma is an airway disorder characterized by bronchial inflammation. An imbalance between the oxidative forces and the antioxidant defense systems has been implicated in the pathogenesis of asthma. Glutathione S-transferases (GSTs) play an important role in cellular protection against inflammation. Several studies have investigated the genetic variability of GSTM1, GSTP1 and GSTT1 enzymes in asthma development with conflicting results. Moreover, in our previous independent case-control study on GSTs and asthma, we have found that  GSTA1  and  GSTO2  gene polymorphisms are associated with asthma. The aim of the present study is to analyze if some functional polymorphisms of  GSTA1 ,  GSTM1 ,  GSTP1 ,  GSTO2  and  GSTT1  are associated with asthma in pediatric patients from Chieti (Italy).

Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children