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Background:  Abnormalities in homocysteine metabolism have been suggested as risk factors for stroke. The aim of this prospective study was to examine whether total plasma homocysteine concentration (tHcy) and its main genetic determinant, methylene tetrahydrofolate reductase ( MTHFR ) polymorphisms, were associated with first ischemic or hemorrhagic stroke.

clinical chemistry and laboratory medicine

Prospective study of first stroke in relation to plasma homocysteine and  MTHFR  677C&gt;T and 1298A&gt;C genotypes and haplotypes – evidence for an association with hemorrhagic stroke