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Background:  Histone deacetylases (HDACs) have been reported to be poor prognostic indicators in patients with cancer. However, no data are available for the role of single nucleotide polymorphism (SNP) of class I HDAC in hepato-cellular carcinoma (HCC). Therefore, we investigated the association of class I HDAC isoforms genomic polymorphisms with risk of HCC and tumor recurrence following liver transplantation (LT).

clinical chemistry and laboratory medicine

Combination of polymorphisms within the  HDAC1  and  HDAC3  gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy