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Background:  Gliomas constitute the vast majority of primary central nervous system tumors in adults. Glioblastoma multiforme (GBM) is the most aggressive form of these primary brain tumors. There is a need to define diagnostic and prognostic markers that may help to distinguish GBM from non-GBM tumors. The Krüppel-like factor 6 ( KLF6 ) gene has recently emerged as a promising candidate. The goal of our study was to determine if there is a link between  KLF6  splice variants expression and different grades of gliomas.

Increased expression of the oncogenic KLF6 -SV1 transcript in human glioblastoma