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Background:  Among markers of pregnancy complications, corticotropin-releasing hormone ( CRH ) mRNA, long pentraxin 3 (PTX3) protein and fetal and total DNA had been reported to be increased in the plasma of women with overt preeclampsia (PE). We developed an optimized protocol to evaluate whether concentrations of  CRH  mRNA,  PTX3  mRNA and protein, fetal and/or total DNA are increased in fetal growth restriction (FGR), and whether they predict complications of pregnancy.

Evaluation of a panel of circulating DNA, RNA and protein potential markers for pathologies of pregnancy