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Background:  Human β-defensins (hBDs) are small cationic, widely expressed proteins involved in innate immunity that exert strong bactericidal activity toward various pathogens. However, the role of hBDs in various diseases to which bacterial infection add severity, as it is in celiac disease (CD), is not yet clear. We analyzed the expression of the  hBD1 ,  hBD2 ,  hBD3  and  hBD4  genes in patients with CD during the active phase and after remission following a gluten-free diet to determine their role in development and relapse of CD.

Low expression of human β-defensin 1 in duodenum of celiac patients is partially restored by a gluten-free diet