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Background : High-density lipoprotein (HDL) is a major plasma lipoprotein directly associated with cholesterol metabolism. The ATP binding cassette transporter 1 gene ( ABCA1 ) is one of the major genes modulating plasma levels of HDL-cholesterol (HDL-C). Rare alleles of  ABCA1  associated with extreme HDL-C concentrations have not been previously investigated in the Chinese.

Novel rare alleles of ABCA1 are exclusively associated with extreme high-density lipoprotein-cholesterol levels among the Han Chinese